Jornada 1
| 11 Sep 21 |  Libertad |
5 - 0 |  Almendros |
... |
| 12 Sep 21 |  Deportivo |
1 - 1 |  Villa Real |
... |
| 18 Sep 21 |  Boliviano |
1 - 4 |  Deportivo |
... |
| 18 Sep 21 |  Unión |
3 - 2 |  Municipal |
... |
| 18 Sep 21 |  Club |
2 - 1 |  Fancesa |
... |
| 18 Sep 21 |  Ferrocarril |
2 - 1 |  Rosario |
... |
| 18 Sep 21 |  Mariscal |
3 - 2 |  Moto Club |
... |
| 19 Sep 21 |  Mojocoya |
4 - 0 |  Atlético |
... |
| 19 Sep 21 |  EM Huanuni |
2 - 1 |  Deportivo |
... |
| 19 Sep 21 |  Quebracho |
0 - 1 |  CA Bermejo |
... |
| 19 Sep 21 |  García |
2 - 1 |  Club |
... |
| 19 Sep 21 |  Deportivo |
3 - 1 |  José |
... |
| 19 Sep 21 |  Wilstermann |
5 - 2 |  América |
... |
| 20 Sep 21 |  Ciudad |
3 - 1 |  Academia |
... |
| 20 Sep 21 |  Torre |
0 - 0 |  Argentinos |
... |
| 22 Sep 21 |  Universitar |
3 - 0 |  Nueva Cliza |
1 |
| 22 Sep 21 |  Cochabamba |
1 - 2 |  Antonio |
3 |
Jornada 2
| 15 Sep 21 | Villa Real |
1 - 2 | Libertad |
... |
| 15 Sep 21 | Almendros |
0 - 1 | Deportivo |
... |
| 22 Sep 21 | Deportivo |
4 - 0 | Municipal |
1 |
| 22 Sep 21 | Unión |
4 - 0 | Boliviano |
1 |
| 22 Sep 21 | Deportivo |
0 - 1 | Deportivo |
1 |
| 22 Sep 21 | José |
0 - 1 | EM Huanuni |
1 |
| 22 Sep 21 | Fancesa |
5 - 0 | Atlético |
2 |
| 23 Sep 21 |  Vaca Díez |
2 - 0 | Moto Club |
1 |
| 23 Sep 21 | Club |
0 - 1 | Mojocoya |
1 |
| 23 Sep 21 | Academia |
0 - 2 | Torre |
1 |
| 22 Sep 21 | CA Bermejo |
2 - 2 | Club |
... |
| 22 Sep 21 | Quebracho |
4 - 2 | García |
... |
| 23 Sep 21 | Argentinos |
1 - 1 | Ciudad |
... |
| 25 Sep 21 | Wilstermann |
2 - 1 | Ferrocarril |
... |
| 25 Sep 21 | Nueva Cliza |
0 - 0 | Antonio |
... |
| 25 Sep 21 | Universitar |
0 - 0 | Cochabamba |
... |
| 26 Sep 21 | América |
1 - 4 | Rosario |
... |
Jornada 3
| 18 Sep 21 | Libertad |
1 - 0 | Deportivo |
... |
| 19 Sep 21 | Villa Real |
2 - 4 | Almendros |
... |
| 25 Sep 21 | Municipal |
2 - 3 | Boliviano |
1 |
| 25 Sep 21 | Deportivo |
3 - 1 | Unión |
... |
| 27 Sep 21 | Ciudad |
1 - 1 | Torre |
... |
| 25 Sep 21 | Mojocoya |
0 - 1 | Fancesa |
... |
| 25 Sep 21 | García |
1 - 1 | CA Bermejo |
... |
| 27 Sep 21 | Argentinos |
4 - 1 | Academia |
4 |
| 25 Sep 21 | Mariscal |
0 - 0 | Vaca Díez |
... |
| 25 Sep 21 | Club |
2 - 1 | Quebracho |
1 |
| 26 Sep 21 | Deportivo |
0 - 3 | EM Huanuni |
... |
| 26 Sep 21 | José |
0 - 4 | Deportivo |
... |
| 26 Sep 21 | Atlético |
1 - 3 | Club |
... |
| 01 Oct 21 | Rosario |
1 - 5 | Wilstermann |
... |
| 29 Sep 21 | Cochabamba |
1 - 0 | Nueva Cliza |
... |
| 29 Sep 21 | Antonio |
2 - 1 | Universitar |
... |
| 01 Oct 21 | Ferrocarril |
1 - 1 | América |
... |
Jornada 4
| 23 Sep 21 | Villa Real |
1 - 1 | Deportivo |
1 |
| 22 Sep 21 | Almendros |
1 - 4 | Libertad |
3 |
| 29 Sep 21 | Fancesa |
0 - 2 | Club |
1 |
| 29 Sep 21 | Atlético |
0 - 2 | Mojocoya |
... |
| 29 Sep 21 | Deportivo |
1 - 3 | EM Huanuni |
... |
| 29 Sep 21 | José |
1 - 5 | Deportivo |
... |
| 30 Sep 21 | Academia |
1 - 3 | Ciudad |
... |
| 30 Sep 21 | Argentinos |
1 - 2 | Torre |
3 |
| 30 Sep 21 | CA Bermejo |
5 - 1 | Quebracho |
... |
| 03 Oct 21 | Vaca Díez |
1 - 1 | Mariscal |
... |
| 01 Oct 21 | Club |
1 - 3 | García |
2 |
| 29 Sep 21 | Unión |
0 - 1 | Deportivo |
... |
| 29 Sep 21 | Boliviano |
5 - 1 | Municipal |
... |
| 03 Oct 21 | América |
0 - 2 | Wilstermann |
... |
| 03 Oct 21 | Rosario |
2 - 1 | Ferrocarril |
... |
| 02 Oct 21 | Antonio |
1 - 0 | Cochabamba |
... |
| 02 Oct 21 | Nueva Cliza |
1 - 3 | Universitar |
... |
Jornada 5
| 03 Oct 21 | Club |
3 - 4 | CA Bermejo |
... |
| 02 Oct 21 | Deportivo |
3 - 2 | Almendros |
... |
| 03 Oct 21 | Atlético |
1 - 1 | Fancesa |
... |
| 04 Oct 21 | Mojocoya |
1 - 1 | Club |
... |
| 03 Oct 21 | Deportivo |
2 - 1 | Deportivo |
... |
| 03 Oct 21 | EM Huanuni |
6 - 1 | José |
... |
| 03 Oct 21 | Libertad |
2 - 0 | Villa Real |
... |
| 03 Oct 21 | García |
2 - 2 | Quebracho |
... |
| 07 Oct 21 | Moto Club |
1 - 3 | Vaca Díez |
... |
| 05 Oct 21 | Torre |
3 - 0 | Academia |
... |
| 05 Oct 21 | Ciudad |
1 - 1 | Argentinos |
... |
| 03 Oct 21 | Municipal |
0 - 8 | Deportivo |
... |
| 03 Oct 21 | Boliviano |
0 - 0 | Unión |
... |
| 07 Oct 21 | Rosario |
2 - 1 | América |
... |
| 06 Oct 21 | Antonio |
3 - 1 | Nueva Cliza |
... |
| 06 Oct 21 | Cochabamba |
1 - 1 | Universitar |
... |
| 07 Oct 21 | Ferrocarril |
0 - 1 | Wilstermann |
... |
Jornada 6
| 07 Oct 21 | Fancesa |
0 - 1 | Mojocoya |
... |
| 08 Oct 21 | Club |
7 - 2 | Atlético |
2 |
| 10 Oct 21 | EM Huanuni |
0 - 2 | Deportivo |
... |
| 10 Oct 21 | Deportivo |
2 - 1 | José |
... |
| 06 Oct 21 | Deportivo |
2 - 0 | Libertad |
... |
| 06 Oct 21 | Almendros |
4 - 3 | Villa Real |
... |
| 09 Oct 21 | Moto Club |
3 - 3 | Mariscal |
... |
| 10 Oct 21 | CA Bermejo |
0 - 4 | García |
... |
| 10 Oct 21 | Quebracho |
2 - 1 | Club |
... |
| 09 Oct 21 | Nueva Cliza |
2 - 4 | Cochabamba |
... |
| 09 Oct 21 | Universitar |
2 - 0 | Antonio |
... |
| 09 Oct 21 | Torre |
1 - 1 | Ciudad |
... |
| 09 Oct 21 | Academia |
2 - 1 | Argentinos |
... |
| 10 Oct 21 | América |
0 - 1 | Ferrocarril |
... |
| 10 Oct 21 | Wilstermann |
2 - 0 | Rosario |
... |
| 08 Oct 21 | Municipal |
1 - 4 | Unión |
... |
| 08 Oct 21 | Deportivo |
6 - 1 | Boliviano |
... |