Jornada 1
| 19 Nov 21 |  Marathón |
1 - 0 |  CD Olimpia |
... |
| 21 Nov 21 | CD Olimpia |
3 - 0 | Marathón |
... |
| 19 Nov 21 |  Lobos UPNFM |
1 - 2 |  FC Motagua |
... |
| 21 Nov 21 | FC Motagua |
3 - 1 | Lobos UPNFM |
... |
Jornada 2
| 05 Dic 21 | FC Motagua |
1 - 1 |  Real |
... |
| 12 Dic 21 | Real |
2 - 0 | FC Motagua |
22 |
| 05 Dic 21 | CD Olimpia |
2 - 0 |  CDyS Vida |
... |
| 12 Dic 21 | CDyS Vida |
2 - 1 | CD Olimpia |
16 |
Jornada 3
| 19 Dic 21 | CD Olimpia |
2 - 0 | Real |
14 |
| 24 Dic 21 | Real |
0 - 1 | CD Olimpia |
121 |
CD Olimpia
FC Motagua
CD Marathón
Real España
CDyS Vida
Lobos de la UPNFM